These side effects may go away during treatment as your body adjusts to the medicine. Some side effects of dexmedetomidine may occur that usually do not need medical attention. unusual excitement, nervousness, or restlessness.seeing, hearing, or feeling things that are not there.pain or discomfort in the arms, jaw, back, or neck.holding false beliefs that cannot be changed by fact.swelling of face, fingers, legs, or ankles.numbness and tingling around the mouth, fingertips, or feet.muscle cramps in the hands, arms, feet, legs, or face.increased menstrual flow or vaginal bleeding.fast, pounding, or irregular heartbeat or pulse.extremely high fever or body temperature.coughing that sometimes produces a pink frothy sputum.pale or blue lips, fingernails, or skin.irregular, fast or slow, or shallow breathing.dizziness, faintness, or lightheadedness when getting suddenly up from a lying or sitting position.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor or nurse immediately if any of the following side effects occur while taking dexmedetomidine: More common Serious side effects of PrecedexĪlong with its needed effects, dexmedetomidine (the active ingredient contained in Precedex) may cause some unwanted effects. Continue reading for a comprehensive list of adverse effects.Īpplies to dexmedetomidine: intravenous solution. Other side effects include: vomiting, and xerostomia. SummaryĬommon side effects of Precedex include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia. Some dosage forms listed on this page may not apply to the brand name Precedex. Note: This document contains side effect information about dexmedetomidine. Dexmedetomidine may be useful as adjunctive therapy however, it cannot be recommended as a single agent in the management of AWS.Īlcohol intoxication central nervous system critical care sedatives substance abuse sympatholytics withdrawal.Medically reviewed by. There was no convincing evidence that dexmedetomidine improves clinical endpoints in patients with AWS, such as need for mechanical ventilation or intensive care unit or hospital length of stay.ĭexmedetomidine reduces hypertension and tachycardia in AWS and also reduces benzodiazepine requirements however, the impact of these findings on important clinical endpoints is yet to be determined. ![]() Overall, dexmedetomidine appears to lower benzodiazepine requirements in patients with AWS and decreases the sympathomimetic response seen in these patients. The only randomized, controlled trial identified showed that the addition of dexmedetomidine decreases benzodiazepine requirements more than placebo in the first 24 hours after initiation compared with the 24 hours prior to initiation (-56.8 mg vs -8 mg P = 0.037). One randomized, controlled trial, 1 prospective observational study, and 6 retrospective reviews were identified. ![]() Case reports and case series describing the use of dexmedetomidine in 10 or fewer patients were excluded. Additional references were identified from a review of literature citations.Īll English-language observational studies, retrospective reviews, and clinical trials were included. Key words included alcohol, withdrawal, delirium tremens, and dexmedetomidine. To review available evidence evaluating dexmedetomidine in alcohol withdrawal syndrome (AWS) while identifying gaps in evidence for its use in this setting.Ī MEDLINE search (1966-August 2015) to identify English-language articles evaluating the efficacy and safety of dexmedetomidine in alcohol withdrawal.
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